Kisspeptin: A Potential Therapathic Target in Patients with Unexplained Infertility?
Kisspeptin has recently emerged as a key regulator of the reproductive axis in women. Kisspeptin, acting centrally via the kisspeptin receptor, stimulates secretion of gonadotrophin releasing hormone (GnRH). Here, we aimed to investigate serum kisspeptin levels in infertility patients for its clinical utilization in management and understanding the pathophysiology of infertility in a wide array of patients.
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This prospective case-control study analysis involved 92 primary infertile women with PCOS, diminished ovarian reserve (DOR), unexplained infertility (UEI), and male factor infertility between 20 and 42 years of age. Serum samples were collected between the second-fifth day of the menstrual cycle. The kisspeptin level was determined using a human kisspeptin ELISA kit according to the manufacturer’s procedure.