Development of pH-sensitive acrylic terpolymers for the coating of orally administered drugs used for colonic release

Published: 22 November 2022| Version 2 | DOI: 10.17632/tvf7jygbb6.2
Contributors:
Lina Suárez, Judith Guasch, Luis Fernando Giraldo, Víctor H Orozco, Miquel Castellote, Lina Hoyos

Description

In this work, a series of polymeric coating formulations were developed by emulsion polymerization from pH-sensitive acrylic monomers. These research results can support the design of coatings for drugs, especially for those that are orally administered and have colonic release. The coatings are suitable for protecting the HPMC capsule at gastric pH (pH= 1.2) and dissolve at a simulated intestinal pH of 7.2. The delivery kinetics of the test molecule occurs over a range of 1 to 4 hours. This range is related to the formulation of the terpolymer, its solubility and the release of the associated API.

Files

Categories

Polymer, Nuclear Magnetic Resonance, Drug Delivery, Fourier Transform Infrared Spectroscopy, Differential Scanning Calorimetry, Scanning Electron Microscopy, Characterization of Zeta Potential of Particle, Transmission Electron Microscopy, Dynamic Light Scattering

Funding

Minciencias

FP44842-211-2018 project 58962

Licence