In Vivo Evaluation of Cucurbita maxima seeds extracts alone and in combination with praziquantel against S. mansoni Infection in Murine Models.

Published: 16 March 2023| Version 1 | DOI: 10.17632/v2h2k8wp3t.1
Floe Mtemeli


The current study was aimed at evaluating the antischistosomal activity of Cucurbita maxima seeds extract alone and in combination with PZQ on Schistosoma mansoni-infected mice . The reduction in total egg count in the C. maxima extract +praziquantel treated group was statically significant with a 72.6% reduction compared to the control group. Combined treatment by C. maxima seeds extract and PZQ induced a significant reduction in the egg count in intestines liver and granuloma size (p=0.01; p=0.02 & p= 0.001) respectively. There was no significant difference in the egg count in intestines, liver and granuloma size from the mice infected by cercariae from the three sites Matimure, Mwedziwandira, and Chikanza (p=0.472; p=0.529& p=0,374) respectively. We observed the synergistic effects of C.maxima extracts in combination with praziquantel and we propose that this combination be considered for human trials.



Life Sciences