Controlling one’s world: identification of sub-regions of primate PFC underlying goal-directed behavior. Duan et al.

Published: 16 June 2021| Version 1 | DOI: 10.17632/v75wdkr2f8.1
Contributors:
,
,
,
,
,
,

Description

Impaired detection of causal relationships between actions and their outcomes can lead to maladaptive behavior. However, causal roles of specific prefrontal cortex (PFC) sub-regions and the caudate nucleus in mediating such relationships in primates are unclear. We inactivated and over-activated five PFC sub-regions, reversibly and pharmacologically: areas 24 (perigenual anterior cingulate cortex), 32 (medial PFC), 11 (anterior orbitofrontal cortex, OFC), 14 (rostral ventromedial PFC/medial OFC) and 14-25 (caudal ventromedial PFC), and the anteromedial caudate, to examine their role in expressing learned action-outcome contingencies using a contingency degradation paradigm in marmosets. Area 24 or caudate inactivation impaired the response to contingency change, while area 11 inactivation enhanced it, and inactivation of areas 14, 32 or 14-25 had no effect. Over-activation of areas 11 and 24 impaired this response. These findings demonstrate distinct roles of PFC sub-regions in goal-directed behavior and illuminate the candidate neurobehavioral substrates of psychiatric disorders including obsessive-compulsive disorder.

Files

Steps to reproduce

R. Lmer, car, predictmeans package

Institutions

University of Cambridge Behavioural and Clinical Neuroscience Institute, Cambridgeshire and Peterborough NHS Foundation Trust, University of Cambridge Department of Psychology, University of Cambridge Department of Psychiatry, University of Cambridge Department of Physiology Development and Neuroscience

Categories

Behavioral Neuroscience

Licence