Supplements-air pollution and atopic dermatitis
Description
The impact of air pollution on atopic dermatitis in European and East Asian populations: a Mendelian randomization study Supplement Tables include:Table 1: Detailed information of data sources.Table 2: Remove SNPs related to AD or its risk factors (p<5e-06, r2<0.001, kb>10000).Table 3: SNPs information of air pollution (European population) with AD.Table 4: SNPs information of air pollution (East Asian population) with AD.Table 5: Analysis results of four methods of univariate Mendelian randomization.Table 6: Summary of sensitivity results.Table 7: Summary of multivariate Mendelian randomization results. Supplement Figures include:Fig 1. Leave-one-out tests of Mendelian randomization analyses for air pollution in atopic dermatitis. (A-J):A. PM2.5 on atopic dermatitis in the European population.B. PM2.5-10 on atopic dermatitis in the European population.C. PM10 on atopic dermatitis in the European population.D. Nitrogen dioxide on atopic dermatitis in the European population.E.Nitrogen oxides on atopic dermatitis in the European population.F.PM2.5_EAS on atopic dermatitis in the Asian population.G.PM2.5-10_EAS on atopic dermatitis in the Asian population.H. PM10_EAS on atopic dermatitis in the Asian population I.Nitrogen dioxide_ EAS on atopic dermatitis in the Asian population.J.Nitrogen oxides_ EAS on atopic dermatitis in the Asian population.
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Steps to reproduce
We selected air pollutant exposure phenotypes from the UK Biobank and published AD gene pooled data from the EAGLE and Finngen studies. Inverse variance weighted was the main analysis method.