Systematic Elucidation and Pharmacological Targeting of Tumor-Infiltrating Regulatory T Cell Master Regulators
Published: 11 April 2023| Version 1 | DOI: 10.17632/vnrsbb4gk9.1
Contributors:
Aleksandar Obradovic, Casey Ager, Mikko Turunen, Thomas Nirschl, Mohsen Khosravi-Maharlooei, Christopher M. Jackson, Srinivasan Yegnasubramanian, Angelo De Marzo, Christina Kochel, Mohamad Allaf, Trinity Bivalacqua, Michael Lim, Ronald Realubit, Charles Karan, Charles G. Drake, Andrea CalifanoDescription
Data accompanying the manuscript "Systematic Elucidation and Pharmacological Targeting of Tumor-Infiltrating Regulatory T Cell Master Regulators"-- includes RNA-Seq of sorted T-cell populations from patients across four tumor types, inferred T-cell ARACNe network, sgRNA counts matrices for pooled CRISPRko screen, PLATE-Seq of drug perturbational experiment, and single-cell RNA-Sequencing of spleen and tumor from gemcitabine-treated versus control mouse Tregs, as well code files used for data analysis.
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Institutions
Columbia University
Categories
RNA Sequencing, Immunotherapy, Drug Screening, Human T Regulatory Cell, Single-Cell RNA Sequencing