Three ESR1 and one ESR2 gene polymorphisms are connected with the presence of metabolic syndrome in postmenopausal women”

Published: 7 March 2018| Version 1 | DOI: 10.17632/vrwb34dhgp.1
Karolina Ku��bicka


Data are connected to the article entitled “Associations of ESR1 and ESR2 gene polymorphisms with the presence of metabolic syndrome and its components in postmenopausal women” sent to Maturitas journal. Objectives: Metabolic syndrome (MS) concerns one fourth of Polish people and leads to diabetes mellitus type 2 and ischemic heart disease. Postmenopausal women are highly affected by MS due to the lack of protective effects of oestrogens. In the near future, because of the extension of life expectancy, the number of postmenopausal women will increase substantially. Therefore, investigating both the environmental and genetic factors predisposing to MS development has a great impact on women’s health. The aim of this study was to find out whether having particular oestrogen receptor (ESR) genes polymorphisms can predispose to the development of MS in women after menopause. Study design: The sample consisted of 147 postmenopausal women. Apart from collecting careful medical history and analyzing body composition, patient’s waist size, blood pressure, serum lipids, glucose, insulin, C-reactive protein and adiponectin were measured. The analysis of ESR genes polymorphisms was performed using Sequenom MassARRAY platform. Results: Three out of ten analyzed polymorphisms in ESR1 gene (rs2234693, rs6902771, rs7774230) and one out of eight analyzed polymorphisms in ESR2 gene (rs3020449) were associated with MS. The ESR1 rs2234693, rs6902771 and rs7774230 polymorphisms were associated with serum high-density lipoprotein concentrations. The ESR2 rs3020449 polymorphism was associated with serum total cholesterol and serum low-density lipoprotein concentrations. Four ESR1 polymorphisms (rs1709183, rs2234693, rs6902771, rs7774230) were associated with total fat tissue content. Conclusions: Bearing the particular alleles at the ESR gene polymorphisms may impact the development of MS and some of the ESR polymorphisms may influence serum cholesterol concentrations in women after menopause.



Gdanski Uniwersytet Medyczny


Endocrinology of Aging