Representative Sets of Singular Non-Hemolytic and Non-Toxic AMPs from Cephalopods' Posterior Salivary Glands Extracted via Network Centralities.

Published: 9 October 2023| Version 1 | DOI: 10.17632/vv5fcxk5rn.1
Guillermin Agüero-Chapin, Dany Domínguez-Pérez, Yovani Marrero-Ponce, Kevin Castillo-Mendieta


These datasets comprise the most representative peptides extracted from a singular set of non-hemolytic and non-toxic antimicrobial peptides (AMPs) sourced from Cephalopods (doi: 10.17632/8mttp4pvmc.1). The selection process involved employing network centrality measures, specifically harmonic and hub-bridge centralities, calculated on the Half-Space Proximal Network used for projecting 5,466 singular AMPs. The smaller dataset (808 peptides) was generated from the peptides identified by both centrality measures, whereas the extended set (2,114 peptides) includes peptides extracted by either centrality measure.


Steps to reproduce

The creation of these datasets followed these key steps: 1. A set of 5,466 singular AMPs sourced from Cephalopods (doi: 10.17632/8mttp4pvmc.1) was projected using the Half-Space Proximal Network (HSPN). 2. Clustering of nodes within the HSPN was performed using the Louvain method. Subsequently, Harmonic (HC) and Hub-Bridge centrality (HB) measures were calculated for each node. 3. The 'scaffold extraction' algorithm from StarPep ( was independently applied using both centrality measures. 4. Two distinct datasets of peptides were extracted based on each centrality measure. 5. The intersection of peptides identified by both centralities resulted in the 'smallest dataset' comprising 808 peptides. Conversely, the union of peptides from both datasets yielded an 'extended dataset' containing 2,114 peptides.


Universidade do Porto Centro Interdisciplinar de Investigacao Marinha e Ambiental


Drug Discovery, Peptides, Cephalopoda, Network (Computer Science), Antimicrobial