AAD Guidelines of Care for the Management of Actinic Keratosis Supplementary File
Description
Background: Actinic keratoses (AK) are rough scaly papules and plaques that arise on chronically ultraviolet (UV)-exposed skin and can progress to squamous cell carcinoma. Treatment options for AK include field-directed therapies, including topical medications and photodynamic therapy, and lesion-directed therapies, including cryosurgery and laser ablation. Objective: This analysis examined the literature related to the management of AK to provide evidence-based recommendations regarding the efficacy, effectiveness, and adverse effects of AK treatment in immunocompetent and immunocompromised individuals. Methods: Work Group members developed clinical questions on the treatment of AK. EMBASE, MEDLINE (via PubMed), and the Cochrane Library were systematically searched for relevant literature. Search results were screened for inclusion, and vetted evaluation tools were used to assess the risk of bias in included studies, to extract data, and to grade the strength and level of evidence supporting each recommendation. Graded recommendations were voted on to achieve consensus.
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Work Group members developed clinical questions on the treatment of AK. EMBASE, MEDLINE (via PubMed), and the Cochrane Library were systematically searched for relevant literature. Search results were screened for inclusion, and vetted evaluation tools were used to assess the risk of bias in included studies, to extract data, and to grade the strength and level of evidence supporting each recommendation.