Short-term time-restricted feeding is safe and feasible in non-obese healthy midlife and older adults

Published: 01-12-2019| Version 3 | DOI: 10.17632/w83t9s27dx.3
Christopher Martens,
Matthew Rossman,
Melissa Mazzo,
Lindsey Jankowski,
Erzsebet Nagy,
Blair Denman,
James Richey,
Sarah Johnson,
brian ziemba,
Yang Wang,
Courtney Peterson,
Michel Chonchol,
Douglas Seals


Chronic calorie restriction (CR) improves cardiovascular function and several other physiological markers of healthspan. However, CR is impractical in non-obese older humans due to potential loss of lean mass and bone density, poor adherence and risk of malnutrition. Time-restricted feeding (TRF), which limits the daily feeding period without requiring a reduction in calorie intake, may be a promising alternative healthspan-extending strategy for midlife and older adults; however, there is limited evidence for its feasibility and efficacy in humans. We conducted a randomized, controlled pilot study to assess the safety, tolerability and overall feasibility of short-term TRF (eating <8h·d-1 for 6 weeks) without weight loss in healthy non-obese midlife and older adults, while gaining initial insight into potential efficacy for improving cardiovascular function and other indicators of healthspan. TRF was safe and well-tolerated, associated with excellent adherence and reduced hunger, and did not influence lean mass, bone density or nutrient intake. Cardiovascular function was not enhanced by short-term TRF in this healthy cohort, but functional (endurance) capacity and glucose tolerance were modestly improved. These results provide a foundation for conducting larger clinical studies of TRF in midlife/older adults, including trials with a longer treatment duration.