Data from "Imputed genomes of historical horses provide insights into modern breeding" Todd et al. (2023) https://doi.org/10.1016/j.isci.2023.107104
Description
Historical genomes can provide important insights into recent genomic changes in horses, especially the development of modern breeds. In this study, we characterized 8.7 million genomic variants from a panel of 430 horses from 73 breeds, including newly sequenced genomes from 20 Clydesdales and 10 Shire horses. We used this modern genomic variation to impute the genomes of four historically important horses, consisting of publicly available genomes from 2 Przewalski’s horses, 1 Thoroughbred, and a newly sequenced Clydesdale. Using these historical genomes, we identified modern horses with higher genetic similarity to those in the past and unveiled increased inbreeding in recent times. We genotyped variants associated with appearance and behavior to uncover previously unknown characteristics of these important historical horses. Overall, we provide insights into the history of Thoroughbred and Clydesdale breeds and highlight genomic changes in the endangered Przewalski’s horse following a century of captive breeding.
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Process Date | 2023-01-03T00:00:00.000Z |
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Publication Title | Imputed genomes of historical horses provide insights into modern breeding |
Publication DOI | doi.org/10.1016/j.isci.2023.107104 |
Citation | Todd, E. T., A. Fromentier, R. Sutcliffe, Y. Running Horse Collin, A. Perdereau, J.-M. Aury, C. Èche, O. Bouchez, C. Donnadieu, P. Wincker, T. Kalbfleisch, J. L. Petersen and L. Orlando (2023). "Imputed genomes of historical horses provide insights into modern breeding." iScience 26(7): 107104. |
Authors | Todd, E. T., A. Fromentier, R. Sutcliffe, Y. Running Horse Collin, A. Perdereau, J.-M. Aury, C. Èche, O. Bouchez, C. Donnadieu, P. Wincker, T. Kalbfleisch, J. L. Petersen and L. Orlando |
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Date | 2023-01-03T00:00:00.000Z |
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University | Centre national de la recherche scientifique, Université Toulouse III - Paul Sabatier |
Address | 37 allées J. Guesde – 31000 Toulouse – FRANCE |
Acknowledgement | The Genoscope sequencing platform is partly funded by the France Génomique National infrastructure, is part of the BUCEPHALE project and was funded by the French Government “Investissement d’Avenir” managed by Agence Nationale pour la Recherche (ANR-10-INBS-09). This work was supported by CNRS and Université Paul Sabatier (AnimalFarm International Research Program, IRP), the France Génomique “Grands Projets” program (BUCEPHALE and MARENGO), and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement 681605 - PEGASUS). Dr Yvette Running Horse Collin was supported by the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement 890702 (MethylRIDE). The bone sample of Baron O’Buchylverie was collected with thanks to BBC Scotland, The Canadian Film for Video Production Tax Credit, The Canadian Media Fund, Clyde Vet Group, Creative Scotland, Glasgow Life, Graven, Infield Fly Productions, Ontario Creates, Rogers Cable Network Fund, and Stream Scotland. |
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