Data for Prefrontal-hippocampal functional connectivity encodes recognition memory and is impaired in intellectual disability

Published: 22 April 2020| Version 1 | DOI: 10.17632/wg4zm32gsb.1
Contributors:
M. Victoria Puig,
Maria Alemany,
Thomas Gener

Description

This dataset contains electrophysiological recordings from euploid mice (EU) and the trisomic (TS) Ts65Dn mouse model of Down syndrome associated with the paper Alemany-González et al. PNAS (2020). The files are in .mat format. Each file includes 12 channels: 3 channels with data recorded from the medial prefrontal cortex (PFC), 3 channels from the CA1 area of the hippocampus (HPC), 3 reference electrodes with no neural activity (REF1 in corpus callosum, REF2 and REF3 in lateral ventricles) and the 3 channels of the accelerometer (x, y, z axis). The names of the files are organized as follows: genotype_mousenumber_brainstate (for example, TS_01_QUIET). The data is organized in three main folders that correspond to the three brain states investigated in the study: - Quiet wakefulness - Natural sleep (REM and NREM) - The novel object recognition task o Familiarization phase o 24-hour memory test - PDF document with detailed description of the dataset In addition, we include data recorded during baseline conditions and after one month of oral treatment with epigallocatequin-3-gallate (EGCG) for the three brain states in trisomic mice only (TS_mousenumber_brainstate_EGCG). There are two additional mice that only received water and are labeled as WAT instead of EGCG. Finally, we also provide data of single-unit spike sorting in .nex format in euploid and trisomic mice for the quiet wakefulness condition. All the results and statistical analyses of the study are summarized in Supporting Tables S2-S4 of the main manuscript.

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Categories

Electrophysiology, Neuropharmacology, Animal Models, Mental Retardation, Down Syndrome, Cognitive Neuroscience, Dynamic Functional Connectivity

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