Relationship Between Real World Evidence Publications and Entresto Sales

Published: 18 November 2024| Version 1 | DOI: 10.17632/wgf5htd2tz.1
Contributors:
Morgan Persky,
, Saif Rathore

Description

This dataset assesses the relationship between the cadence of RWE publications and sales of sacubitril/valsartan (Entresto®) following launch. The data reveal that an additional RWE-related publication was associated with an estimated mean increase in quarterly sales of $1.8M (from quarter q to q+1 following publication), $3.5M (from q+1 to q+2), and $2.7M (from q+2 to q+3). In adjusted models, an additional RWE publication was associated with a mean gain in sales from quarter q+1 to q+2 of $2.6M. RWE publications were not associated with an increase in sales in the quarter following publication, and the association was attenuated by third quarter following publication.

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Publication data were derived from a PubMed search over 7/01/2015–12/31/2023 for English-language, human subjects’ studies with the drug name (Entresto® or sacubitril) and indication (heart failure) in the title or abstract. Quarterly RWE publication data were combined with quarterly information on sacubitril/valsartan sales over the 34-quarter period spanning Q3 2015 through Q4 2023. Quarter-to-quarter change in total sales was modeled with linear regression as a function of counts of previously published RWE-related studies, adjusting for a linear time trend to control for any underlying trends in sales growth; change in total sales from the quarter prior to publication to the quarter of publication to control for recent sales changes; and the cumulative count of RWE publications from Q3 2015 through the previous quarter to control for the contribution of previous RWE publications to future sales.

Categories

Health Economics, Cardiology

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