Eosinophil cationic protein is a potential surrogate marker of allergic contact dermatitis: A single-center, retrospective study of 216 patients

Published: 6 April 2020| Version 1 | DOI: 10.17632/wgr5tckfh5.1
jemin kim


Supplement Table 1. Frequency of sensitization to allergens from the patch test in allergic contact dermatitis patients. Supplement Table 2. Correlations of total eosinophil count, total IgE, and disease duration with serum ECP in ACD and non-ACD groups. Supplement Table 3. Comparison of serum allergy markers between ACD and AD-ACD groups. Supplement Figure 1. (A) ROC curve testing whether serum ECP differentiates ACD from non-ACD patients (B) ROC curve testing of total IgE. ROC, Receiver operating characteristic; AUC, Area under curve Supplement Figure 2. Dermal eosinophil density from skin biopsy specimens of ACD patients was not correlated with their serum ECP levels (r = 0.21, p = 0.82). Among the study patients, 15 patients underwent a skin biopsy of lesional skin. Two board-certified dermatologists (J.H.K and Y.I.L) independently reviewed the hematoxylin and eosin sections. The presence of eosinophilic spongiosis and dermal eosinophil density were scored in a semi-quantitative manner. HPFs, High power fields.



Yonsei University College of Medicine


Allergic Contact Dermatitis