Adult Lung Health Study

Published: 28 September 2020| Version 1 | DOI: 10.17632/whbk485wbw.1
Sarah Rylance


The Adult Lung Health Study was a propective cohort study conducted in Chikhwawa, rural Malawi, between August 2014 and November 2017. The published manuscript can be found at Data were collected at baseline and 2 follow-up visits from a population-representative sample of adults (aged 18 or over). At each time-point participants completed a respiratory symptom questionnaire, performed pre- and post-bronchodilator spirometry and underwent a 48-hour period of personal air pollution monitoring. 1481 adults were recruited between August 2014 and July 2015. Spirometry data (meeting BOLD [Burden of Obstructive Lung Disease] Study QC standards) were collected for 886 participants at baseline, 594 participants at first follow-up and 537 participants at second follow-up. Spirometry was performed before and after administration of 200 microgram salbutamol, via Volumatic spacer. Spirometry measurements were considered repeatable if there were 2 acceptable traces within 200ml of each other. Personal air pollution exposure data were collected using Aprovecho monitors (measuring carbon monoxide and fine particulate matter), worn by each participant for a period of 48-hours. In order to minimise missing data and ensure measurements represented a full 24-hour cycle, readings were truncated at 24-hours. Aprovecho data were available for 1029 participants at baseline, 830 at first follow-up and 811 at second follow-up.



Liverpool School of Tropical Medicine Department of Clinical Sciences, Malawi-Liverpool-Wellcome Trust Clinical Research Programme