Overactive mitochondrial DNA replisome causes neonatal heart failure via ferroptosis - Supplemental data

Published: 7 December 2023| Version 2 | DOI: 10.17632/wm2dhwpghm.2
, Tuomas Laalo, Steffi Goffart, Riikka Kivelä, Karlo Skube, Anni I Nieminen, Sara Wickström, James Stewart, Anu Suomalainen


Characterization and multi-omics analysis of the hearts of mice carrying an exonuclease-deficient DNA polymerase gamma and overexpressing Twinkle helicase. Includes numeric values used for plots, uncropped and representative echocardiography videos and transmission electron micrograms, and data from mitochondrial DNA deep-sequencing, transcriptomic, metabolomic, proteomic analyses. For further methodological details please refer to the associated original publication.


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See related original publication of the same name.


Helsingin Yliopisto, Jyvaskylan Yliopisto, Wellcome Trust Centre for Mitochondrial Research, Ita-Suomen yliopisto, Wihurin Tutkimuslaitos, Newcastle University


Proteomics, Metabolomics, Transcriptomics, Echocardiography, Physiological Measurement, mtDNA