Overactive mitochondrial DNA replisome causes neonatal heart failure via ferroptosis - Supplemental data

Published: 7 December 2023| Version 2 | DOI: 10.17632/wm2dhwpghm.2
Contributors:
Juan Cruz Landoni, Tuomas Laalo, Steffi Goffart, Riikka Kivelä, Karlo Skube, Anni I Nieminen, Sara Wickström, James Stewart, Anu Suomalainen

Description

Characterization and multi-omics analysis of the hearts of mice carrying an exonuclease-deficient DNA polymerase gamma and overexpressing Twinkle helicase. Includes numeric values used for plots, uncropped and representative echocardiography videos and transmission electron micrograms, and data from mitochondrial DNA deep-sequencing, transcriptomic, metabolomic, proteomic analyses. For further methodological details please refer to the associated original publication.

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Steps to reproduce

See related original publication of the same name.

Institutions

  • Helsingin Yliopisto
  • Jyvaskylan Yliopisto
  • Wellcome Trust Centre for Mitochondrial Research
  • Ita-Suomen yliopisto
  • Wihurin Tutkimuslaitos
  • Newcastle University

Categories

Proteomics, Metabolomics, Transcriptomics, Echocardiography, Physiological Measurement, mtDNA

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