Aerosol delivery of star polymer-siRNA nanoparticles as a therapeutic strategy to inhibit lung tumor growth

Published: 9 June 2022| Version 1 | DOI: 10.17632/wmfcw7cksx.1
Contributor:
Zerong Ma

Description

These datasets were used for the manuscript "Aerosol delivery of star polymer-siRNA nanoparticles as a therapeutic strategy to inhibit lung tumor growth". Here we performed an in-depth characterization of cell uptake, intracellular trafficking, and gene silencing activity of miktoarm star polymer (PDMAEMA-POEGMA) nanoparticles (star nanoparticles) complexed to siRNA in lung cancer cells. We also investigated the potential of nebulized star-siRNA nanoparticles to accumulate into orthotopic mouse lung tumors to inhibit the expression of two genes (βIII-tubulin, PLK1) which: 1) are highly expressed in lung cancer cells; 2) play an important role in promoting tumor growth; and 3) are difficult to inhibit using chemical drugs. All raw data are available below and quantitative analysis can be reproduced from this dataset.

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Categories

Lung Cancer, Small Interfering RNA, Nanomedicine

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