Dataset on NU7441, a DNA-dependent kinase inhibitor, in splenic lymphocyte differentiation and lymphocyte infiltrations in tumor microenvironment in a mouse model with xenograft of 4T1 triple negative breast cancer
Description
Triple negative breast cancer (TNBC) is highly malignant and refractory to blockage of PD-1/L1 immunotherapy due to the impediment of immune cell infiltration in tumor microenvironment (TME). We investigated the effects of a DNA-dependent kinase (DNA-PK) inhibitor, NU7441, on lymphocyte infiltration in TNBC TME. 4T1 murine TNBC cells were utilized to construct a xenograft mouse model in immune competent BALB/c mice. The influence of NU711 on CD4+CD45+、CD8+CD45+ T cells and CD1a+CD45+ antigen presenting cells in TME of xenograft mice was tested through flow cytometry. The splenic CD4+CD45+、CD8+CD45+ T cells and CD1a+CD45+ antigen presenting cells in xenograft mice were also detected through flow cytometry. The associations of DNA-PK with immune cell infiltrations in TME of clinical breast cancer patients were analyzed through tumor immune estimation resource. These data demonstrate association of inhibition of DNA-PK and infiltrations of anti-tumoral lymphocytes in TME of TNBC, which provide a strategy to alter infiltration of anti-tumoral lymphocytes in TME and may contribute to enhancing the efficacy of immunotherapy to TNBC.