A study of Unraveling CD4+ T Cell Diversity and Tissue Adaptation of Tregs in Abdominal Aortic Aneurysms through Single-Cell Sequencing. Luna Zhai et al.
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We observed the heterogeneity of CD4+ T cells and identified a group of more activated, proliferated, and developed aorta Tregs in abdominal aortic aneurysms. These Tregs originate in the spleen and acquire the tissue-specific phenotype in the aorta. Figure 6 shows flow cytometry analysis of T cell subgroups in AAA spleen and aorta. Figure 7 treg precursor cluster in the spleen identified by adoptive transfer.
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Luna Zhai et al Figure 6.zip Fig.6a Th1 Fig6a.ppt Fig6a.pzfx Fig6a.xls Fig.6b Th17 Fig6b.ppt Fig6b.pzfx Fig6b.xls Fig.6c-d Treg Fig6c-d.ppt Fig6c-d.pzfx Fig6c-d.xls Fig.6e Th2 Fig6e.ppt Fig6e.pzfx Fig6e.xls Fig.6f Pie charts Fig6f.ppt Fig6f.pzfx Fig6f.xls Fig.6g left+6h KLRG1+ Fig.6g left+6h.ppt Fig.6g left+6h.pzfx Fig.6g left+6h.xls Fig.Fig.6g right+6i ST2+ Fig.6g right+6i.ppt Fig.6g right+6i.pzfx Fig.6g right+6i.xls Luna Zhai et al Figure 7.zip Fig.7b CD45.1+ Treg percentage Fig7b.ppt Fig7b.pzfx Fig7b.xls Fig.7c ST2+ Treg percentage Fig7c.ppt Fig7c.pzfx Fig7c.xls