Dataset for HADS manuscript

Published: 9 May 2022| Version 1 | DOI: 10.17632/wxnzj4f4cm.1
Faisal Parlindungan


Rheumatoid arthritis (RA) patients have a greater prevalence of anxiety and depression. Proinflammatory cytokines are elevated in RA. We aim to evaluate the association between systemic inflammation in RA and anxiety and depression. Serum proinflammatory cytokines were measured, including interleukin (IL)‐6, IL‐17, and Tumour Necrosis Factor-alpha (TNF‐α). Among 31 patients, ten patients showed anxiety symptoms, 19 patients showed depression symptoms, and two displayed mixed symptoms. Serum TNF-α levels were significantly higher in active disease than in the remission group. There was no association and correlation between proinflammatory cytokines to anxiety and depression symptoms in the active disease and remission groups. This finding suggests that other factors besides disease activity and state of systemic inflammation may cause anxiety and depression in RA patients


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Collected data were analyzed using SPSS 20.0 (SPSS INC., Chicago, IL, USA) for Mac. Descriptive data were presented in the form of the mean (Standard Deviation) when they are normally distributed or median (min-max) when they are not normally distributed. Statistical analyses for the differences in cytokine levels between active and remission and within the disease activity with and without anxiety and depression were compared using the Mann–Whitney U-test when they are not normally distributed and independent t-test when they are not normally distributed. Spearman's rank correlation explored the correlations between proinflammatory cytokines, disease activity, anxiety and depression. All statistical tests were 2-sided, and P values less than 0.05 were significant.


Autoimmune Disorder