Data for: Blockade of TRPV1 receptors and FAAH endocannabinoid enzyme within the nucleus accumbens shell elicits anxiolytic-like effects in male rats.
The functional role of the endocannabinoid system (ECS) and the TRPV1 receptors within the Nucleus Accumbens shell (NAc shell) remains unknown. Preclinical studies reported that the ECS modulates emotional responses. High density of CB1 and TRPV1 receptors are co-localized within the NAc shell. Therefore, ECS-TRPV1 interactions within the NAc shell might play a modulatory role in anxiety response.The present study aims to establish the role of ECS-TRPV1 interactions within the NAc shell on mediating anxiety. It is hypothesized that neurochemical regulation elicited by ECS within the NAc shell mediate anxiety-like behaviors in rodents.