Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.

Name: Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.
Creator: Andrea Pruijssers
Published: 2020-06-25T18:43:49.617Z
Keywords: Antiviral Drug, Severe Acute Respiratory Syndrome Coronavirus 2

Pruijssers, Andrea

doi:10.17632/x3sw5z2bg9.1

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.

Published: 25 June 2020| Version 1 | DOI: 10.17632/x3sw5z2bg9.1

Contributor:

Andrea Pruijssers

Description

Model of the elongating SARS-CoV-2 polymerase complex generated based on a homology model which used the cryo-EM structure of apo SARS-CoV as a template (PDB: 6NUR)

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.

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