Diagnosis and Management of Yellow Nail Syndrome: An International Multi-Institutional Retrospective Cohort Study of 111 Cases by an Expert Panel

Published: 15 July 2025| Version 1 | DOI: 10.17632/xc7zyk2f4m.1
Contributors:
Kaya Curtis, Bianca Maria Piraccini, Michela Starace, Luca Rapparini, Bertrand Richert, Adam Rubin, Nathaniel Jellinek, Antonella Tosti, Nilton Gioia Di Chiacchio, Nilton Di Chiacchio, Matilde Iorizzo, Chander Grover, Molly Hinshaw, Tracey Vlahovic, Jane Bellet, Dimitris Rigopoulos, Shari Lipner

Description

Supplemental Table 1. Characteristics of yellow nail syndrome patients. Supplemental Table 2. Most common combinations of nail findings of 99 patients with yellow nail syndrome with documented physical examination. Supplemental Table 3. Level of evidence for yellow nail syndrome treatment recommendations. Supplemental Figure 1. 43-year-old male with yellow nail syndrome. Patient had history of bronchiectasis and remote Hodgkin’s lymphoma. Physical examination is notable for xanthonychia, increased transverse curvature, nail thickening, and missing lunulae. Supplemental Figure 2. 17-year-old Indian male with yellow nail syndrome. There are thickened and opaque yellow nails with increased curvature. There was distal onycholysis affecting multiple nails and distal nail clippings showed the presence of yeast forms. The patient also had a history of chronic cough and persistent post-nasal drip suggestive of sinusitis. Supplemental Figure 3. 73-year-old male with yellow nail syndrome and Pseudomonas infection of the bilateral thumbnails. Patient had concurrent pulmonary hypertension, pulmonary fibrosis, and lymphedema of the lower extremities. Physical examination is notable for xanthonychia, increased transverse curvature, nail thickening, and opacity. There is green discoloration of the bilateral thumbnails. Appendix.

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Categories

Dermatology, Nail, Nail Abnormality

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