Canonical PRC1 recruitment is promoted by EZH1-1 PRC2 independent of H3K27me3 in quiescent cells

Published: 27 January 2023| Version 1 | DOI: 10.17632/xggmj66c9b.1
Contributor:
Adrian Bracken

Description

Raw Western blots of paper, entitled "Canonical PRC1 recruitment is promoted by EZH1-1 PRC2 independent of H3K27me3 in quiescent cells". A Non-Catalytic Role of EZH1-PRC2 to Promote Canonical PRC1 Recruitment in Quiescent Cells Evan Healy1,2*, Rachel McCole1*, James Nolan1,3, Craig Monger1, Eric Conway1,4, Gerard L. Brien1, Cheng Wang1, Orla Deevy1, Hannah K. Neikes5, Frances Potjewyd6, Aoibhinn Mooney7,8, Richard Flavin7,8, Elisabeth Vandenberghe3, Sarena F. Flanigan2, Chen Davidovich2,9, Michiel Vermeulen5, Lindsey I. James6,10, Adrian P. Bracken1†. 1Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland. 2Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia. 3Department of Haematology, St. James’ Hospital, Dublin 8, Ireland. 4School of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland. 5Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University Nijmegen, 6525 GA Nijmegen, The Netherlands. 6Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. 7Department of Histopathology, St. James’ Hospital, Dublin 8, Ireland. 8Department of Histopathology, Trinity College Dublin, Dublin 2, Ireland. 9EMBL-Australia, Clayton, VIC, Australia. 10Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. *These authors contributed equally. †Corresponding author: Dr. Adrian P. Bracken (adrian.bracken@tcd.ie).

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Institutions

Smurfit Institute of Genetics Trinity College

Categories

Cell Proliferation, Chromatin

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