Spatial and latent memory data in PS2Tg2576 Alzheimer’s disease mouse model after memantine treatment

Published: 31 March 2021| Version 3 | DOI: 10.17632/xxrsf4nr7v.3
Yasushi Kishimoto,
Masahisa Matsumura,
Kana Sato,
Takashi Kubota


We present data on whether memantine, an adamantane derivative and medical NMDA-receptor antagonist, improves spatial and latent learning deficits in amyloid precursor protein/presenilin 2 double-transgenic mice (PS2Tg2576 mice). PS2Tg2576 mice were subjected to Morris water maze (MWM) test for spatial memory and the water-finding test for latent memory testing at ages 3 and 5-6 months. At 3 months of age, the learning performance of PS2Tg2576 mice was normal compared to wild-type mice in both tasks. At 5-6 months of age, cognitive deficits were observed in the MWM and water-finding test; 3-4 weeks of memantine treatment (30 mg/kg/day, p.o.) significantly reverted the learning deficits in the MWM; however, had little effect on those in the water-finding test. The information provided in this report adds to the literature and can be used for the selection of animal models and behavioral paradigms for Alzheimer's disease (AD) research.