Spatial and latent memory data in PS2Tg2576 Alzheimer’s disease mouse model after memantine treatment

Published: 31 March 2021| Version 3 | DOI: 10.17632/xxrsf4nr7v.3
Yasushi Kishimoto, Masahisa Matsumura,


We present data on whether memantine, an adamantane derivative and medical NMDA-receptor antagonist, improves spatial and latent learning deficits in amyloid precursor protein/presenilin 2 double-transgenic mice (PS2Tg2576 mice). PS2Tg2576 mice were subjected to Morris water maze (MWM) test for spatial memory and the water-finding test for latent memory testing at ages 3 and 5-6 months. At 3 months of age, the learning performance of PS2Tg2576 mice was normal compared to wild-type mice in both tasks. At 5-6 months of age, cognitive deficits were observed in the MWM and water-finding test; 3-4 weeks of memantine treatment (30 mg/kg/day, p.o.) significantly reverted the learning deficits in the MWM; however, had little effect on those in the water-finding test. The information provided in this report adds to the literature and can be used for the selection of animal models and behavioral paradigms for Alzheimer's disease (AD) research.



Teikyo Daigaku, Tokushima Bunri Daigaku - Kagawa Campus


Behavioral Neuroscience, Pharmaceutics