Cartilage Creep Duration Dataset
Description
Confined and unconfined, ex vivo, creep compression experiments were carried out on 20 full-thickness bovine cartilage samples (6 mm diameter) harvested from the lateral femoral condyle at weight-bearing areas using a razor blade and a 6-mm diameter biopsy punch. An Instron material testing machine (Model 5944, Instron, Norwood, MA, US) used a 2-kN load cell (Model 2580-107, Instron, Norwood, MA, US) to perform confined and unconfined creep experiments under force-controlled settings. To ensure smooth contact with the sample, a slow displacement rate of 0.01 mm/s was applied until the preload of 0.05 MPa was reached. The preload stress was then maintained for 15 min allowing the sample to reach a baseline thickness. Afterwards, the force was ramped up at a rate of 0.25 MPa/s until the desired creep load of 1 MPa. Hereafter, the creep load was maintained for 5 hours while force and displacement data were recorded continuously at a sampling rate of 10 Hz. Initial sample thickness was determined as the last thickness measured at the end of preload and engineering strain was computed and normalised to that instance of time. For both confined and unconfined experiments, samples were mounted in a testing chamber fully immersed in phosphate-buffered saline (PBS). Confined experiments were performed by loading the sample with a rigid cylindrical piston (6 mm diameter) in a cylindrical chamber (6.2 mm diameter) with a porous plate (nominal pore size of 40 µm), allowing fluid to flow out of the tissue while confining radial expansion. Unconfined experiments were conducted by positioning the sample in an open chamber and using a rigid cylindrical piston (12 mm diameter) to apply the stress. After either test configuration, the tissues were allowed to relax in PBS for 24 hours before being retested. The data file (CreepDurationData.mat) consist of one file for MATLAB where the data is saved in a struct. - The first layer is the test configuration layer to distinguish between unconfined and confined experiments. - The second layer is the sample layer and has all 20 samples. - The third layer is the actual data for each specific sample. Within this layer is the initial thickness estimation. As well as four vectors with time, displacement, force and strain data. Within the Database are the .csv files with the actual data recorded during the experiments as well as the scripts to take out the data from the .csv files. This can be done by running the DataHandling.m to open and extract the data.
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Funding
Novo Nordisk Foundation
NNF21OC0065373