The potential role of phytochemicals in non-alcoholic fatty liver disease (NAFLD) through modulation of forkhead box O1 (FOXO1) transcription factor signaling pathways; a review
Description
Literature evidences reveal that natural compounds are potential candidates for ameliorating obesity associated non-alcoholic fatty liver disease (NAFLD) by targeting forkhead box O1 (FOXO1). FOXO has dual and complex role in regulating both increase and decrease in lipids accumulation in hepatocytes and adipose tissues (AT) at different stages of NAFLD. In insulin resistance (IR), FOXO1 is constitutively expressed, resulting in increased hepatic glucose output and lipids metabolism irregularity. The studies on different phytochemicals indicate that dysregulation of FOXO1 causes disturbance in cellular nutrients homeostasis. The current review communicates and evaluates certain phytochemicals through different search engines, targeting FOXO1 and its downstream cellular pathways, to find lead compounds as potential therapeutic agents for treating NAFLD and related metabolic disorders. The findings of this review confirm that polyphenols, alkaloids, terpenoids and anthocyanins are capable of modulating FOXO1 and related signaling pathways and they are potential therapeutic agents for NAFLD and related complications.