Association between skin microbiota and keratinocyte carcinomas: insight from mendelian randomization
Published: 23 July 2024| Version 1 | DOI: 10.17632/y4s9vf7dtj.1
Contributors:
Zhijie Ruan, Wenbo Zhou, Guolong Zhang, Yun Wu, Chunying Li, Qingyu Zeng, Xiuli WangDescription
Keratinocyte carcinomas (KCs), specifically cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC), have been associated with alterations in the skin microbiome. However, it remains unclear whether the alterations reflect carcinogenic or anticancer properties, or if they merely represent an ecological niche. Mendelian randomization (MR) is a robust approach to estimate causal effects between traits. Here, we conducted a two-sample MR and Meta-analysis to investigate the causal association between skin microbiota and KCs (cSCC and BCC) among European populations.
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Institutions
Shanghai Skin Diseases Hospital, Tongji University School of Medicine
Categories
Basal Cell Carcinoma, Microbiota, Squamous Cell Carcinoma, Mendelian Randomization
Funding
Ministry of Science and Technology of the People's Republic of China
No. 2022YFC2504700 and 2022YFC2504705