Data for: Endogenous Retinoic Acid Theory and Retinoic Acid Depletion Syndrome

Published: 17-09-2020| Version 1 | DOI: 10.17632/yc26zg925z.1
aziz rodan sarohan


This study present two new concepts and definitions to the medical literature. One of those is “endogenous retinoic acid theory” and the other “retinoic acid depletion syndrome”. A new classification will be provided for the immune system: “retinoic acid dependent component” and “retinoic acid non-dependent component”. If this theory is verified, all the diseases where the retinoic acid metabolism is defective and retinoic acid levels are low will be identified and new approaches will be developed fortreating such diseases. Prevention, through intrinsic mechanisms or medications, of the excretion of pre-stored retinoic acids through liver cytochrome oxidase enzymes and increasing retinoic acid levels to therapeutic levels in cases where the body’s need for retinoic acids increases, such as acute infection, high fever, extreme catabolic process and continuous antigenic impulse, is called “Endogenous Retinoic Acid Theory”. Retinoic acids also manage their own metabolisms with feedback mechanisms. Despite such compensatory mechanisms, the retinoic acid stores of the body get depleted due to overuse of the RIG-I pathway and the Type-I interferon synthesis patway, which include retinoic acid receptors, because of reasons such as high fever, severe catabolic process and oversized viral genome (SARS-CoV-2). As a result, the RIG-I path is passivated, causing excessive TNFα and cytokine discharge over the NFκB arm by shifting to TLR3, TLR7, TLR8, TLR9, MDA5 and UPS pathways in the mechanism, adaptive immune defense neutrophils, macrophages and dendritic cells. Depletion of retinoic acid stores as a result of such overuse, leading to shifting of the immune defense mechanism to the NFκB arm, where retinoic acid cannot be used and which results in cytokine release, is called ‘’retinoic acid depletion syndrom’’. COVID-19 and each of the previously defined sepsis, SIRS and ARDS are essential a retinoic acid depletion syndrome. We claim that retinoic acid metabolism is defective especially in COVID-19 (cytokine storm) most inflammatory diseases such as sepsis, SIRS and ARDS. Finding a solution to this mechanism will require a new perspective and treatment approach to such diseases.