Proteome-Wide Bioinformatic Annotation and Functional Validation of the Monotopic Phosphoglycosyl Transferase Superfamily

Published: 24 October 2024| Version 1 | DOI: 10.17632/yg333b6j3b.1
Contributors:
Theo Durand,
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Description

Optimized Sequence Similarity Networks (SSNs) of the SmPGT family allowing for functional annotation of clusters as validated in the published work. Datasets S1-S4 and S6 can all be visualized using Cytoscape. Dataset S1 is the network file for the E-value 1x 10-61, 100% representative node SmPGT network. Dataset S2 is the Cytoscape session file, with applied coloring, of the E-value 1x 10-61, 100% representative node SmPGT network. Dataset S3 is the network file for the E-value 1x 10-71, 100% representative node SmPGT network. Dataset S4 is the Cytoscape session file, with applied coloring, of the E-value 1x 10-61, 100% representative node SmPGT network. Dataset_5 is the Genome Neighbourhood Network of the E-71 SSN, viewable as diagrams on the EFI-EST server. Dataset_S6 is Genome Neighbourhood Diagrams of the clusters from the E-71 SSN, with the clusters as hub-nodes and neighbouring Pfam families as spoke-nodes

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Steps to reproduce

See publication doi: https://doi.org/10.1101/2024.07.10.602977

Institutions

Massachusetts Institute of Technology, Imperial College London, Boston University

Categories

Enzyme Inhibitor, Glycoconjugate, Membrane Protein, Biosynthesis Pathway, Functional Analysis, Glycobiology

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