Increased Risk of Renal Disease in Patients with Hidradenitis Suppurativa
Description
Supplemental Data from TriNetX for manuscript entitled: "Increased Risk of Renal Disease in Patients with Hidradenitis Suppurativa" Background: Hidradenitis suppurativa (HS) has been linked to systemic comorbidities, but effects on kidney health remain underrecognized. Objective: Quantify the risk of major renal outcomes in adults with HS. Methods: Retrospective cohort study using de-identified electronic health records (2005-2025) from 102 TriNetX network institutions. Adults with HS were 1:1 propensity-matched to acne controls on age, sex, race/ethnicity, hypertension, diabetes, and nicotine dependence (231,036 pairs). Using ICD-10 codes, new-onset chronic kidney disease, acute kidney injury, end-stage renal disease, and dialysis requirement were tracked from one day post-index through available follow-up (~3 years). Cumulative incidence, risk ratios (RR), and Cox hazard ratios (HR) were calculated. Results: HS cohort with higher incidence of CKD (3.4% vs 2.9%; RR 1.16; HR 1.30), AKI (4.3% vs 3.0%; RR 1.41; HR 1.59), ESRD (0.6% vs 0.4%; RR 1.38; HR 1.54), and dialysis (0.7% vs 0.4%; RR 1.55; HR 1.73); p < 0.001. Kaplan-Meier curves indicated earlier and more frequent renal dysfunction in HS. Limitations: Observational design, diagnosis code reliance, and ~45% subjects missing data body-mass index may inflate risk estimates. Conclusion: Adults with HS face a meaningful increase in incident and progressive kidney disease, stressing the need for routine renal risk assessment in HS.