RNAseq analysis HFD mice
Published: 9 July 2019| Version 1 | DOI: 10.17632/yjj46v5c27.1
Contributors:
Adriana Carino, , Description
Non alcoholic Fatty Liver Disease (NAFLD) is a common hepatic disorder with a prevalence in Western and Asian countries of 20-30%. Obeticholic Acid (OCA), is effective in attenuating lier staetosis, inflammation and fibrosis in in vivo experimental models and later in clinical trials. Ursodeoxycholic acid (UDCA), is a safe and unexpensive bile acid used in the treatment of liver disorders whose mechanism of action is poorly defined. OCA and UDCA effect were evaluated in a mouse model of steatohepatitis by RNAseq analysis performed on Ion S5 Sequencer with Torrent Suite Software v6.
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Institutions
Universita degli Studi di Perugia
Categories
Gastroenterology