Acute graft-versus-host disease presenting as Stevens–Johnson syndrome and toxic epidermal necrolysis: a retrospective cohort study

Published: 4 April 2022| Version 1 | DOI: 10.17632/ym4yfwhk7r.1
Yi-Teng Hung,


3 Supplementary Figures and 1 Supplementary Table Mendeley supplemental figure 1. Clinical pictures of a patient with Stevens–Johnson syndrome/toxic epidermal necrolysis-like acute graft-versus-host disease. (A) Lip erosion and oral mucositis. (B) Generalized dusky-red, atypical target flat maculopatches on the trunk with focal erosions around the nipples. (C) Diffuse beef-red erosions on the penis and scrotum. Mendeley supplemental figure 2. Histopathology of skin lesions of Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN)-like acute graft-versus-host disease (aGVHD). Hematoxylin-eosin staining of the skin lesions of SJS/TEN-like aGVHD shows (A) basal cell vacuolization, dyskeratotic cells, and pigment incontinence with follicular involvement (original magnification: × 100) and (B) subepidermal bullae, numerous dyskeratotic keratinocytes, basal cell vacuolization, and inflammatory cells at interface and around dermal vessels (original magnification: × 200). Mendeley supplemental figure 3. Kaplan–Meier curves for probability of survival in acute graft-versus-host disease patients. Comparison of 2-month (acute stage) survival in acute graft-versus-host disease (aGVHD) patients with Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN)-like cutaneous manifestations (n=15) and without SJS/TEN (n=16) was performed with the Kaplan–Meier method. The dashed line (red) showed that SJS/TEN-like aGVHD patients had a trend of decreased 2-month survival (p=0.064) since diagnosis of aGVHD compared with SJS/TEN-like aGVHD patients, shown as real line (blue). SJS, Stevens–Johnson syndrome; TEN, toxic epidermal necrolysis Mendeley supplemental table 1. Treatment and prognosis for acute graft-versus-host disease with/without Stevens–Johnson syndrome and toxic epidermal necrolysis symptoms



Chang Gung Memorial Hospital Linkou Branch


Dermatology, Steven-Johnson Syndrome, Graft-versus-Host Disease, Toxic Epidermal Necrolysis