Exploiting Multi-Omics Profiling And Systems Biology to Investigate Functions of TOMM34

Name: Exploiting Multi-Omics Profiling And Systems Biology to Investigate Functions of TOMM34
Creator: Ekaterina Poverennaya
Published: 2022-12-06T18:04:31.613Z
Keywords: Gene Knockout

Poverennaya, Ekaterina; Pyatnitskiy, Mikhail; Dolgalev, Georgii; Arzumanian, Viktoriia; Kiseleva, Olga; Kurbatov, Ilya; Kurbatov, Leonid; Vakhrushev, Igor; Kim, Yan; Ponomarenko, Elena

doi:10.17632/yrmd8ygncn.1

Exploiting Multi-Omics Profiling And Systems Biology to Investigate Functions of TOMM34

Published: 6 December 2022| Version 1 | DOI: 10.17632/yrmd8ygncn.1

Contributors:

Ekaterina Poverennaya, Mikhail Pyatnitskiy, Georgii Dolgalev, Viktoriia Arzumanian, Olga Kiseleva, Ilya Kurbatov, Leonid Kurbatov, Igor Vakhrushev, Yan Kim, Elena Ponomarenko

Description

Here, we report genes and pathways associated with TOMM34, Translocase of OuterMitochondrial Membrane which plays role in the mitochondrial protein import as a part of cytosoliccomplex together with Hsp70/Hsp90 and upregulated in various cancers. We identified genes,proteins and metabolites altered in TOMM34 -/- HepG2 cells. To our knowledge, this is the firstattempt to study the functional capacity of TOMM34 using a multi-omics strategy.

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Naucno-issledovatel'skij institut biomedicinskoj himii imeni V N Orehovica

Exploiting Multi-Omics Profiling And Systems Biology to Investigate Functions of TOMM34

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