Emergence and Increased Epidemic Potential of Dengue Variants with the NS5V357E Mutation after Consecutive Years of Transmission

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We discover the molecular events involved in overwintering and increased disease severity between consecutive dengue virus serotype 2 outbreaks from 2001 to 2003 in Taiwan. The virus evolved from the early-epidemic strain (Ia) to the late-epidemic strains (Ib and II), featuring three amino acid differences. The data for plaque and foci morphology in Figures 1 and 2, is provided.

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