Baseline Characteristics and Perioperative Outcomes of Patients Undergoing Total Hysterectomy via Transumbilical Single-Port versus Multiport Laparoscopy
Description
This study is a prospective single-center, randomized, single-blind, parallel-group controlled clinical trial comparing MPLS and TU-LESS for hysterectomy in patients with benign gynecologic conditions. Conducted at the Department of Gynecology, First Affiliated Hospital of Soochow University, the trial randomized eligible participants 1:1 to MPLS or TU-LESS using a computer-generated permuted block randomization system. All procedures were performed by experienced gynecologic surgeons (≥25 prior TU-LESS cases).Statistical analyses were conducted using IBM SPSS Statistics (version 25.0). Continuous variables are presented as mean ± standard deviation (SD), while discrete variables as median (interquartile range [IQR]). Normality of continuous variables was assessed using Shapiro-Wilk tests. Normally distributed data were compared with independent t-tests; non-normally distributed data were analyzed with Mann-Whitney U tests. Categorical variables are reported as frequencies (%) and analyzed with Pearson’s χ² tests. A two-tailed P-value < 0.05 was deemed statistically significant. The primary outcome was the 24-hour postoperative composite ERAS compliance rate. Secondary outcomes included operative time, intraoperative blood loss, transfusion rate, uterine weight, time to first flatus, time to drain removal, 24-hour postoperative visual analogue scale (VAS) pain score, postoperative hospital stay, 3-month postoperative complications, and Patient and Observer Scar Assessment Scale (POSAS) scores. In this work, we compared enhanced recovery after surgery and perioperative outcomes in patients with benign gynecological diseases undergoing total hysterectomy via multi-port laparoscopic surgery versus transumbilical laparoendoscopic single-site surgery.The findings demonstrate that TU-LESS provides safety and feasibility equivalent to MPLS while conferring distinct advantages in postoperative recovery and scar concealment.
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Funding
Financial support for this study was provided by the Suzhou Key Lab of Multi-modal Data Fusion and Intelligent Healthcare
No: 25SZZD05