prolactin and epilepsy

Published: 24 February 2020| Version 1 | DOI: 10.17632/yzd6hj5zv8.1


In this research we aimed to investigate the correlation between the prolactin hormone level and damage to hippocampus tissue in experimental epilepsy model. In literature some authors found out that prolactin hormone level increase in epileptic seizures and can be protective in terms of hippocampal damage. 24 wistaria-hannover rat were used for experimental epilepsy model induced with pilocarpine. Prolactin hormone levels were decreased with bromocriptine. We found out that prolactin hormone increased after seizure and it was statistically significant. It was seen that, hemorrhages occurred in surface of the brains in lower prolactin level group, but we couldn't found a statistically significant histologic data for more hippocampal damage. This research can give more reliable and significant results when re-planned with larger sample groups.