Sevoflurane Sedation Protocol in Children with Cerebral Palsy Undergoing BotulinumToxin-A Injections - DATABASE

Published: 15 April 2020| Version 1 | DOI: 10.17632/z2b6tcgyb5.1


Objective: To investigate the safety and efficacy of a protocol based on sevoflurane sedation for the control of pain and agitation during botulinum toxin infiltration in children with cerebral palsy. Design: Retrospective observational study. Setting: Sedations were performed in a tertiary children's hospital from November 2012 to December 2019. Patients: Infiltrations with BoNT-A were carried out under sevoflurane sedation in 75 children with cerebral palsy. Methods: Initially, unconsciousness is achieved by inhaling 8% sevoflurane through a Mapleson-D system, then deep sedation is maintained with a fresh gas mixture with 2.5-4.0% inspired sevoflurane during intramuscular injections. Main Outcome Measurements: Demographic characteristics, clinical and functional characteristics, the effectiveness of sedation, adverse events (AE), and professional satisfaction were reviewed.



Junta de Andalucia Servicio Andaluz de Salud, Universidad de Cadiz


Rehabilitation, Anesthesia, Cerebral Palsy, Procedural Pain, Spasticity, Child Rehabilitation