Molecular profiles of the hepatic response to caloric restriction in rhesus monkeys

Published: 29 September 2017| Version 1 | DOI: 10.17632/z4cttg3gp3.1
Tim Rhoads,
Maggie Burhans,
Vincent Chen,
Paul Hutchins,
Matthew Rush,
Jaime Stark,
Sean McIlwain,
Hamid Eghbalnia,
Derek Pavelec,
Irene Ong,
John Denu,
John Markley,
Joshua Coon,
Ricki Colman,
Rozalyn Anderson


This dataset contains data derived from liver biopsy tissue collected at two time points from young adult rhesus macaques (Macaca mulatta). The animals were an all-male subset of a larger study begun at the University of Wisconsin-Madison in 1989. The study was designed to examine the consequences of caloric restriction (CR) on a non-humane primate model organism. This data comes from male monkeys on control and CR diets at the time they were enrolled in the study, and after two years of study diet. This was combined with other molecular profiling techniques (RNA-Seq, shotgun lipidomics, NMR metabolomics) to examine the longitudinal, molecular changes accompanying short-term CR.



University of Wisconsin Madison Department of Medicine


Proteomics, Macaca mulatta, Molecular Profiling, Calorie Restriction