Data for: CYP2C9 (*2&*3) and CYP2C19 (*2&*3) polymorphisms among Egyptian children with primary epilepsy: A case control study.

Published: 12-10-2020| Version 2 | DOI: 10.17632/z8432k2bg6.2
Contributors:
Yahya Wahba,
AFAF EL-SAID,
Samah Eltalal,
Mostafa El Ayouty

Description

Background: Epilepsy is a common neurological disorder with proven genetic basis. Cytochrome (CYP) P450 enzymes are responsible for antiepileptic drugs (AEDs) metabolism, and encoded by highly polymorphic genes including CYP2C9 (*2 &*3) and CYP2C19 (*2 & *3). Methods: We conducted a case control study in Egypt from 2015 to 2017 including 50 AEDs responders, 50 AEDs resistant cases and 50 controls. Participants were assessed clinically and for CYP2C9 (*2 & *3) and CYP2C19 (*2 & *3) using PCR. Results: CYP2C9*2 (CT) genotype & (T) allele were more frequent in resistant and responsive groups than controls (P<0.001). (TT) genotype was more frequent in resistant than responsive group (P=0.02, OR = 12, 95%CI =1.2-122.3). No significant differences were detected between resistant and responsive groups regarding CYP2C9*2 alleles (P=0.2). CYP2C9*3 (AC) genotype & (C) allele were more frequent in resistant and responsive groups than controls (P<0.001). No significant differences were detected between resistant and responsive groups regarding neither CYP2C9*3 genotypes nor alleles (P=0.11, 0.2 respectively). CYP2C19*2&*3 (GA) genotypes & (A) alleles were more frequent in resistant and responsive groups than controls (P<0.001). No significant differences were detected between resistant and responsive groups regarding neither genotypes nor alleles (P= 0.21, 0.89 for CYP2C19*2 & P=1, 0.77 for CYP2C19*3). Younger age of onset, higher seizure frequency and CYP2C9*2 (TT) genotype were significant predictors for refractory epilepsy. Conclusion: Heterozygous genotypes and mutant alleles of CYP2C9 (*2&*3) and CYP2C19 (*2&*3) were more frequent among Egyptian children with primary epilepsy. CYP2C9*2(TT) genotype increased the risk of refractory epilepsy.

Files