Data from: Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks
The data in this collection relates to the publication titled “Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks”, authored by Wright, Leger, et al. The majority of the collection is dedicated to the phenotypic and genetic data presented in figure two of the manuscript, and for related traits collected for this study. This collection also included raw phenotypic measurements for each of the 6,147 rats used in this study. GWAS data was collected and analyzed as described in “Genome-Wide Association Study in 3,173 Outbred Rats Identifies Multiple Loci for Body Weight, Adiposity, and Fasting Glucose” by Chitre et al., 2020 in continuation of this study. Additionally, this collection contains genotype data collected as part of the NIDA Center for GWAS in Outbred rats and more than 10 additional research projects that use N/NIH heterogeneous stock (HS) outbred rats. We obtain genotypes for DNA samples derived from rats that are phenotyped by different research projects. We use these genotypes to perform genome wide association studies (GWAS) and a number of related analyses.
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Rodents were phenotyped, genotyped, and GWAS was preformed as described in 'Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks' by Wright, Leger et al. 2023 Cell Reports.