Crocin pretreatment Improved Spatial Memory in acute high altitude hypoxia rats
We first performed MWM to evaluate the cognitive performance of different groups of rats.The MWM test (Fig. 1D) showed a significant increase in escape latency time (Fig. 1B) and travel distance (Fig. 1C) in the AHH group compared with the control group (p<0.05). The same study showed a significant decrease in escape latency time and travel distance in the groups pretreated with crocin at all the concentrations used compared with the AHH group (p<0.05). Among the crocin-treated groups, HHG group had the best protective effect on hippocampus compared with LHG group (p <0.05) and HMG group (p <0.05).