Egger et al., Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates, Cell reports (2024)

Published: 12 March 2024| Version 1 | DOI: 10.17632/zdb9ccrpm6.1
Contributors:
Tom EGGER, Jihane Basbous

Description

Mendeley Data set containin all the raw data presented throughthout Egger et al., Cell reports (2024). Egger et al. implement their previously proposed ATR/Chk1 activation model by dissociating the functions of ATR and Chk1. Using reverse genetics and optogenetics, they show that Chk1 is phosphorylated at the interface of TopBP1 biomolecular condensates, triggering cell cycle checkpoints and slowing down replication fork progression.

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Institutions

BioCampus Montpellier, Universite Montpellier Faculte des Sciences de Montpellier, CNRS Delegation Languedoc-Roussillon

Categories

Cell Biology, DNA Replication, DNA Damage Response

Funding

Agence Nationale de la Recherche

ANR-10-INBS-04

Agence Nationale de la Recherche

AAPG2021

MSDAVENIR

Licence