Lithium Chloride Promotes Lipid Accumulation through Increased Reactive Oxygen Species Generation

Published: 17 Jun 2019 | Version 1 | DOI: 10.17632/zdsrg335bg.1
Contributor(s):

Description of this data

Lithium salts are commonly used to treat bipolar disease. Despite the frequent prescription of long-term lithium therapy, awareness of obesity, the most serious side-effect, and the mechanisms by which lithium influences lipid metabolism are largely unknown. In the present study, we gained valuable insights into the mechanisms underlying the lipogenic action of lithium by examining its effects on lipid accumulation in both cells and the zebrafish system. We have presented evidence for the first time that lithium induces lipid accumulation through stimulation of intracellular ROS generation via a GSK-3β-independent pathway. Our findings may facilitate the development of novel therapeutic targets to ameliorate side effects of lithium therapy in psychotic patients.

Experiment data files

Latest version

  • Version 1

    2019-06-17

    Published: 2019-06-17

    DOI: 10.17632/zdsrg335bg.1

    Cite this dataset

    Lee, Yunkyoung (2019), “Lithium Chloride Promotes Lipid Accumulation through Increased Reactive Oxygen Species Generation”, Mendeley Data, v1 http://dx.doi.org/10.17632/zdsrg335bg.1

Statistics

Views: 28
Downloads: 10

Institutions

Inha University

Categories

Lipid Biosynthesis

Licence

CC BY 4.0 Learn more

The files associated with this dataset are licensed under a Creative Commons Attribution 4.0 International licence.

What does this mean?

This dataset is licensed under a Creative Commons Attribution 4.0 International licence. What does this mean? You can share, copy and modify this dataset so long as you give appropriate credit, provide a link to the CC BY license, and indicate if changes were made, but you may not do so in a way that suggests the rights holder has endorsed you or your use of the dataset. Note that further permission may be required for any content within the dataset that is identified as belonging to a third party.

Report