Data for: Cytokine profiles of Necator americanus and Plasmodium falciparum co-infected patients in rural Ghana
Description
Cytokine profiles of Necator americanus and Plasmodium falciparum co-infected patients in rural Ghana The study presented here evaluated stool and blood samples collected from Necator americanus and Plasmodium falciparum mono- and co-infected individuals and characterized circulating cytokine plasma levels before and after albendazole treatment. Malaria parasitaemia was significantly reduced in hookworm and P. falciparum co-infected individuals (p=0.0018) while hookworm intensity was similar between groups. IL-10 level was significantly higher in the co-infected individuals (39.9± 12.2 pg/ml) compared to the single infected or the uninfected group (10.7±7.6 mg/ml). IL-5 level was higher in the hookworm only infected individual. TNF-α levels were higher in all infected groups compared to the uninfected controls. CCL11 levels were significantly higher in subjects infected with hookworm only or co-infected with hookworm and P. falciparum. There was a significantly negative correlation (rs = -0.39, p=0.021) between hookworm eggs per gram of stool and CCL11 levels in the group mono-infected with hookworm which was not affected by treatment. Treatment with albendazole led to a significant reduction of TNF-α (p=0.041), IL-5 (p=0.01) and IL-10 (p=0.001) levels.