Data for: Safety evaluation of seagrass Thalassia testudinum extract in acute and subchronic oral toxicity studies.
Published: 11 April 2020| Version 1 | DOI: 10.17632/zkm7p6fvgr.1
Contributor:
Alicia LagartoDescription
The data show the processed and raw data for the evaluation of the acute and subchronic toxicity of Thalassia testudinum extract by oral route in mice and rats. Acute toxicity test was conducted by oral route at doses between 50 and 2000 mg/kg in both sexes’ mice. For the subchronic study, rats were administered with three doses (100, 500 and 2000 mg/kg/day) by oral route for 90 days. Acute toxicity test revealed any signs of toxicity. The approximate lethal dose of the extract was higher than 2000 mg/kg. Significant and dose depend increase of urea and decrease of creatinine were observed in treated male animals in subchronic study. These variations did not represent any functional impairment for test animals and were reversible.
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Institutions
Centro de Bioproductos Marinos, Centro de Investigacion y Desarrollo de Medicamentos
Categories
Experimental Toxicology, Seagrass