Hyaluronic acid/PEO electrospun tube reduces tendon adhesion to levels comparable to native tendons – an in vitro and in vivo study
We produced an electrospun DegraPol® tube containing a layer of hyaluronic acid/polyethylene oxide with the aim to use HA as biolubricant and improve the anti-adhesive effect of the DegraPol® tube. As hyaluronic acid/polyethylene oxide was the first time added to DegraPol electrospun scaffolds, material properties were analyzed with SEM, Fourier-transformed infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Water Contact Angle (WCA), and by testing the mechanical qualities. Tubes were applied in a full laceration rabbit Achilles tendon and three weeks after implantation, the adhesion extent of the extracted Achilles tendons was determined using Picrosirius Red staining.
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung