Hyaluronic acid/PEO electrospun tube reduces tendon adhesion to levels comparable to native tendons – an in vitro and in vivo study

Name: Hyaluronic acid/PEO electrospun tube reduces tendon adhesion to levels comparable to native tendons – an in vitro and in vivo study
Creator: Iris Miescher
Published: 2023-12-20T16:17:57.585Z
Keywords: Extracellular Matrix, Adhesion, Fourier Transform Infrared Spectroscopy, Differential Scanning Calorimetry, Electrospinning, Mechanical Failure, Hyaluronic Acid, Achilles Tendon, In Vivo Study, Animal Tendon Healing

Miescher, Iris

doi:10.17632/zr7rvp6str.2

Hyaluronic acid/PEO electrospun tube reduces tendon adhesion to levels comparable to native tendons – an in vitro and in vivo study

Published: 20 December 2023| Version 2 | DOI: 10.17632/zr7rvp6str.2

Contributor:

Iris Miescher

Description

We produced an electrospun DegraPol® tube containing a layer of hyaluronic acid/polyethylene oxide with the aim to use HA as biolubricant and improve the anti-adhesive effect of the DegraPol® tube. As hyaluronic acid/polyethylene oxide was the first time added to DegraPol electrospun scaffolds, material properties were analyzed with SEM, Fourier-transformed infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Water Contact Angle (WCA), and by testing the mechanical qualities. Tubes were applied in a full laceration rabbit Achilles tendon and three weeks after implantation, the adhesion extent of the extracted Achilles tendons was determined using Picrosirius Red staining.

Hyaluronic acid/PEO electrospun tube reduces tendon adhesion to levels comparable to native tendons – an in vitro and in vivo study

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