DATASET FOR FACTOR V LEIDEN IN SUBJECTS WITH PREECLAMPSIA

Published: 6 November 2019| Version 3 | DOI: 10.17632/zvbbtby75p.3
Contributors:
Grace Ababio,
null null,
Emmanuel Abindao,
Grace Narh,
Diana Tetteh,
Felix Botchway,
Diana Morvey,
Jonathan Kotey Neequaye,
Isaac Quaye

Description

In Ghana, there is limited information regarding factor V Leiden polymorphism on the pathogenesis of preeclampsia (PE) and its associated outcomes; hence, the focus of the current study. Eighty-one (81) consented subjects were recruited after ethical clearance was obtained and structured questionnaire administered to them. Routine blood chemistry and characterization of Factor V Leiden were obtained for subjects. We found FVL mutation much more in PE and hypertensive patients. FVL exon 10 were 0.67 and 0.33 for G and A alleles respectively. There was an absence of FVL mutation in exon 8 in the current study. Increased white blood cells, increased uric acid and a three – fold increment of AST / ALT ratio were observed among PE cases when stratified by FVL exons (exon 8 and 10). This study was the first to report baseline FVL genotypic and allelic frequencies as well as relating clinical variables with it.

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Coagulation Factor V

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