Soman-induced status epilepticus and spontaneous recurrent seizures in rats: raw EDF files in support of Data in Brief communication

Published: 23 September 2019| Version 2 | DOI: 10.17632/zwcx948yjc.2
Contributors:
Lucille Lumley,
Franco Rossetti,
Marcio de Araujo Furtado,
Brenda Marrero-Rosado,
Mark Schultz,
Jerome Niquet,
Claude Wasterlain

Description

In addition to experiments detailed in Niquet et. al [1,2] we determined the efficacy of a dose range of midazolam (MDZ) when administered at a delayed time point after seizure onset in protecting against soman (GD)-induced status epilepticus (SE) and epileptogenesis. Adult male rats implanted with telemetry transmitters for the continuous recording of electroencephalographic (EEG) activity were exposed to 132 µg/kg GD and treated (i.m.) with atropine sulfate (2 mg/kg) and the oxime HI-6 DMS (118.5 mg/kg) at one min after GD exposure, and MDZ (1, 3, 9 mg/kg, i.p.) at 40 min after SE onset. EEG recordings were analyzed using a MATLAB algorithm [3]; data for SE onset and duration, and onset of spontaneous recurrent seizures (SRS) for over a month after exposure were provided as a supplement to the communication in the form of a spreadsheet. The present dataset contains raw telemetry recordings from four animals exposed to GD and treated with MDZ. Each folder contains EEG data of each animal compressed into 7zip format split into 3 volumes (to facilitate upload to data repository). Their nomenclature includes the animal's number, followed by GD and the dose of MDZ that they received (MDZ1, MDZ3, or MDZ9). Rats' identifications were removed and dates set back to 2000, per IACUC suggestion. Two animals from the 3 mg/kg MDZ group, A05 and A09, are provided; the former showed over 25 SRS, and the latter over 100 SRS. A06 received 1 mg/kg MDZ and presented over 30 SRS. Animal A08 treated with 9 mg/kg MDZ showed less than 5 SRS. Gaps of short duration are observed throughout the recordings as animals were weighed daily. Longer gaps in the recordings coincide with behavioral assessment periods when rats were removed from the receiver. We suggest https://www.7-zip.org for uncompressing files prior to opening them in a EDF (European Data Format)-compatible software. The sample files are of value to others who may wish to further analyze changes in EEG patterns that may be useful in identifying types of seizure activity or power changes. They might help the scientific community to test seizure detection and prediction algorithms which can accelerate the evaluation of drug efficacy against GD-induced status epilepticus and epileptogenesis. 1. Niquet, J., Lumley, L., Baldwin, R., Rossetti, F., Suchomelova, L., Naylor, D., Estrada, I.B.F., Wasterlain, C. G. (2019a) Rational polytherapy in the treatment of cholinergic seizures. Neurobiol Dis., 104537 2. Niquet J., Lumley, L., Baldwin, R., Rossetti, F., Schultz, M., de Araujo Furtado, F., Suchomelova, L., Naylor, D., Estrada, I.B.F., Wasterlain, C.G. (2019b) Early polytherapy for benzodiazepine-refractory status epilepticus. Epilepsy Behav., in press. 3. de Araujo Furtado, M., Zheng, A., Sedigh-Sarvestani, M., Lumley, L., Lichtenstein, S., Yourick, D. (2009) Analyzing large data sets acquired through telemetry from rats exposed to organophosphorous compounds: an EEG study. J Neurosci Methods, 184(1), 176-183.

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Status Epilepticus, Electroencephalography, Chemical Warfare Agent

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