Pneumococcal Carriage in Infants Post-PCV10 Introduction in Pakistan
This data set is from the study "Pneumococcal Carriage in Infants Post-PCV10 Introduction in Pakistan: Results from Serial Cross-Sectional Surveys" published in the journal Vaccine which can be accessed from 'Shahid S, Khan A, Nisar MI, Khalid F, Qazi MF, Ahmed S, Kabir F, Hotwani A, Muneer S, Ali SA, Whitney CG, Zaidi AKM, Jehan F. Pneumococcal Carriage in Infants Post-PCV10 Introduction in Pakistan: Results from Serial Cross-Sectional Surveys. Vaccines (Basel). 2022 Jun 18;10(6):971. doi: 10.3390/vaccines10060971. PMID: 35746579; PMCID: PMC9230137.' We conducted a serial cross-sectional study exploring the impact of 10-valent Pneumococcal Conjugate Vaccine (PCV10) on nasopharyngeal (NP) carriage in children under 2 years from Matiari, Pakistan. Data was collected from 665 children on socio-demographic and clinical characteristics, and vaccination status using an online questionnaire. NP samples were collected using standard World Health Organization (WHO) techniques, culture and serotyping were done using sequential Multiplex PCR described by the Centre for Disease Control, USA. We looked at the carriage rate of vaccine-type (VT) and non-vaccine type (NVT) serotypes over time in vaccinated and unvaccinated children. PCV10-specific nasopharyngeal carriage decreased both in the population indicating herd immunity.